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Standard health advice assumes everyone's body works the same way. It doesn't. Pathway reads your existing 23andMe or AncestryDNA data and shows you exactly how your body processes nutrients differently — and what to do about it.
Don't have your DNA file yet? You'll need a 23andMe or AncestryDNA kit first — then come back.
Pairs with your Folate Activator variant — which may raise how much choline your body needs.
A fresh study on your MTHFR variant just landed — we refreshed how it informs your plan.
Most never find out. MTHFR is the gene for an enzyme that turns the folate you eat into the active form your body can actually use. A common variant makes that step less efficient — so you may do better with the already-active methylfolate form, and may need a little more folate and B12 to keep things running smoothly.
Normal variation — not a disease, not a diagnosis. Many carriers feel completely fine; knowing simply lets you cover your bases.
The variant slows the middle step — so the active 5-MTHF form can suit you better than plain folic acid.
A standard blood panel tells you your nutrient levels right now. It can't tell you how efficiently your body converts and uses those nutrients — that's written in your genes. For the full picture, you need both.
You need both halves. Pathway reads the genetic one — and shows how it fits with your labs.
No quizzes, no guesswork. We read what's already in your 23andMe or AncestryDNA data, then turn it into a plan you can act on. Set it up in five minutes, refine it forever.
From 23andMe or AncestryDNA. Processed securely — you stay in control of your data.
Across methylation, neuro, metabolic, vitamin D and more — explained in plain language.
A daily supplement stack and habits matched to your genetics — with a tracker to make it stick.
Your body may convert B vitamins to their active forms a little slower than average — so the methylfolate form can suit you better than plain folic acid. This is normal variation, not a deficiency.
Sits alongside your Folate Activator variant. Together they can slow methylation more, which may raise how much choline your body needs — so we lift your daily choline target to 680 mg.
You may clear dopamine and adrenaline at a moderate pace — so we go gentle with methyl donors and shift caffeine-sensitive supplements earlier in the day.
Every pill on your list has a reason behind it. Tap any row to see which variant put it there — and what happens if you skip it. Your protocol adapts as your goals change.
Two-hour separation between minerals. Vitamin D with fat. Methyl donors before COMT's peak — we handle the timing so the chemistry actually works.
“Why am I taking this?” answered in two plain sentences, with the underlying variant cited and a link to the research.
Pregnancy, fasting, marathon training, a glass of wine — flip a mode and the protocol rebalances. Liver days, travel days, recovery days.
Export the protocol as a shopping list, a doctor's note, or a JSON file. Your data is yours — leave any time without losing it.
Genetics is easy to oversell. We built Pathway to do the opposite — to tell you what we can actually see, in language you can actually use, and to be clear about the limits.
We tell you exactly which markers your provider's data covered — and never pretend “not tested” means “you're fine.”
Every finding leads with what it means for you, not Latin gene names.
Findings are sorted from most important to fine-tuning, so you know what actually matters first.
Anything worth raising with your physician is called out separately, in a format they can read fast.
Most genetics products want to sell you another kit, then hand you a dense report. Pathway reads the data you already own — and turns it into something you actually use every day.
| Pathway You're here | SuperpowerLab membership | LifeDNADNA reports | Gene GenieDNA reports | |
|---|---|---|---|---|
| Uses your existing 23andMe / AncestryDNA dataNo new kit to buy | ✓ | — | ~ | ~ |
| Plain-language explanationsNot raw gene jargon | ✓ | ✓ | ✓ | ~ |
| Personalized supplement plan | ✓ | ~ | ✓ | ~ |
| Daily supplement trackerBuilt in, not a PDF | ✓ | — | — | — |
| Interaction & timing reminders | ✓ | — | — | — |
| Doctor-ready summary | ✓ | ✓ | — | — |
| Ongoing guidance & chat | ✓ | ✓ | — | — |
| Free core results | ✓ | — | — | ~ |
Comparison based on publicly available information, June 2026. Competitor offerings change — check their sites for the latest.
Pathway helps you understand your genetics and have better conversations with your doctor — it doesn't diagnose, treat, or replace medical care. Your data is yours; delete it anytime.
Your core results are free. Unlock your full Optimal Stack, daily tracker, and ongoing guidance for $9/month — cancel anytime.
Your core results, free.
The full tracker, monthly.
For practitioners.
Can't find what you're looking for? We answer every email within a business day — written by a human, often the one who built the feature.
Email support →No. Pathway is an educational tool that translates published research about common genetic variants into practical, food-and-supplement-level suggestions. It does not diagnose, treat, or cure any condition. If you take medication or have a health condition, talk to your doctor before changing your supplement routine — and bring your Pathway report to the appointment.
23andMe (v3, v4, v5), AncestryDNA, MyHeritage, FamilyTreeDNA, Nebula Genomics, tellmeGen, and any raw text export following the dbSNP rsID convention. We're adding direct integrations as services open up APIs.
Pathway is built around your 23andMe or AncestryDNA data — that's where the personalization comes from. If you don't have a kit yet, order one from either service, then upload your raw data file here when it arrives.
Those tools dump every variant they can find onto a long PDF. We do the opposite: a tight 22-marker set chosen for nutritional consequence and replicated evidence, paired with a daily tracker that actually changes behavior. The science is also explained — not just cited — so you can decide whether to trust each call.
Yes. Every protocol exports as a one-page PDF with doses, timing, rationale, and variant citations — a format clinicians have told us they can read in 90 seconds. There's also a separate clinician dashboard if your practitioner wants to manage multiple clients.
You get an email link to download everything — your variant calls, your protocol history, your tracker logs — as a single JSON archive. Thirty days later, your account is permanently deleted unless you ask us to wait longer. No dark patterns.
Fair question — nutrigenomics has been oversold, and plenty of direct-to-consumer “DNA diet” claims run well ahead of the evidence. So we're deliberately conservative: Pathway focuses on a small set of variants where the research is genuinely strong, and we label how solid each finding is rather than treating them all as equal.
The clearest example is MTHFR C677T and folate. A large meta-analysis in JAMA (Klerk et al., 2002) linked the 677 TT genotype to higher homocysteine and a modestly higher cardiovascular risk, and that risk was most pronounced where folate intake was low — i.e. the effect is real but partly modifiable through nutrition. Decades of folate-metabolism work (reviewed in the Journal of Nutrition and by the NIH Office of Dietary Supplements) show this variant can raise how much folate some people need and can favor the already-active methylfolate form. Conversion of plant omega-3 (ALA) to EPA/DHA is similarly shaped by FADS1 variants, documented across several population studies.
The honest caveat: effect sizes are usually moderate, they interact with diet, lifestyle and your actual blood levels, and many other marketed variants have far weaker support. That's why Pathway is educational rather than diagnostic, links every finding to its sources, and recommends pairing your results with bloodwork and your doctor — not replacing them.
Upload your existing 23andMe or AncestryDNA data and see your core results free. Unlock the full plan whenever you're ready — cancel anytime.