Citations

Every variant, traceable.

The 32 variants Pathway analyzes, grouped by pathway, each linked to its canonical entry in NCBI's dbSNP registry. Full peer-reviewed reference lists are being compiled — see the note at the bottom.

Methylation

Folate and B12 activation, homocysteine recycling, choline demand. · 8 variants

MTHFRC677Trs1801133
moderate evidence
dbSNP →
MTHFRA1298Crs1801131
moderate evidence
dbSNP →
MTRRA66Grs1801394
moderate evidence
dbSNP →
MTRA2756Grs1805087
moderate evidence
dbSNP →
CBS699C>Trs234706
moderate evidence
dbSNP →
BHMTR239Qrs3733890
moderate evidence
dbSNP →
MTHFD1R653Qrs2236225
emerging evidence
dbSNP →
PEMTV175Mrs7946
moderate evidence
dbSNP →

Histamine

Histamine breakdown and caffeine clearance. · 2 variants

HNMTThr105Ilers2073440
moderate evidence
dbSNP →
CYP1A2CYP1A2*1F (-163C>A)rs762551
strong evidence
dbSNP →

Neuro

Dopamine/adrenaline clearance and synaptic plasticity. · 4 variants

COMTVal158Metrs4680
strong evidence
dbSNP →
COMTHis62His (synonymous)rs4633
moderate evidence
dbSNP →
COMT3'UTR variantrs165599
moderate evidence
dbSNP →
BDNFVal66Metrs6265
moderate evidence
dbSNP →

Vitamin D

Sunlight conversion, transport, and cellular uptake of vitamin D. · 4 variants

CYP2R1rs10741657rs10741657
moderate evidence
dbSNP →
CYP2R1rs2060793rs2060793
moderate evidence
dbSNP →
VDRTaqIrs731236
moderate evidence
dbSNP →
GCAsp416Glurs7041
moderate evidence
dbSNP →

Inflammation

Baseline set-points for innate-immune signaling. · 5 variants

TNF-308G>Ars1800629
strong evidence
dbSNP →
TNF-238G>Ars361525
strong evidence
dbSNP →
IL6-174G>Crs1800795
strong evidence
dbSNP →
TGFB1-509C>Trs1800469
moderate evidence
dbSNP →
IL10-1082G>Ars1800896
moderate evidence
dbSNP →

Blood sugar & metabolic

Type-2-diabetes-associated variants and evening glucose control. · 4 variants

TCF7L2IVS3C>Trs7903146
strong evidence
dbSNP →
TCF7L2IVS3G>Trs12255372
strong evidence
dbSNP →
MTNR1Brs10830963rs10830963
moderate evidence
dbSNP →
MTNR1Brs1387153rs1387153
moderate evidence
dbSNP →

Pharmacogenomics

How you metabolize common drug classes — surfaces as doctor flags, not supplement recommendations. · 5 variants

CYP2C19CYP2C19*2rs4244285
strong evidence
dbSNP →
SLCO1B1V174Ars4149056
strong evidence
dbSNP →
OPRM1A118Grs1799971
moderate evidence
dbSNP →
ABCB1C1236Trs1128503
moderate evidence
dbSNP →
CYP1B1L432Vrs1056836
moderate evidence
dbSNP →

References being compiled

Full peer-reviewed reference lists — the specific studies behind each variant's effect size, tier assignment, and clinical interpretation — are being assembled and reviewed before publication here. Rather than list references we haven't verified against the current scoring rules, the links above go to dbSNP, NCBI's canonical variant registry, where every rsID resolves to its definitive record with population frequencies and cross-references to ClinVar and PharmGKB. Complete citations will be added when they're ready. If a variant here surprises you or you know a study that should inform its scoring, please get in touch.

How scoring worksEducational, not diagnostic